标题:One-Pot Synthesis of Quinoxalinones via Tandem Nitrosation/Cyclization of N‑Aryl Cyanoacetamides
Abstact:A new one-pot strategy for the synthesis of quinoxalin-2-ones from the tandem nitrosation/cyclization reaction of N-aryl cyanoacetamides with tert-butyl nitrite has been developed. The dehydrogenative N-incorporation is achieved through a sequence of nitrosation, tautomerization, and cyclization, affording quinoxalin-2-ones in moderate to good yields with good functional group tolerance.
原文:
http://doi.org/10.1021/acs.joc.7b01930