个人简介

刘洪鑫，男，博士，硕士生导师。2018年毕业与中国科学院成都生物研究所，同年进入BAT365唯一官网。主要研究方向：(1) 有机小分子不对称催化合成；(2) 基于DNA体系的仿生不对称催化；(3) 手性药物开发设计。在Green Chem., Org. Lett., Org. Chem. Front., Chem. Commun.，Chem-Eur. J., Frontiers in Chemistry 等国际期刊发表多篇论文。现主持浙江省自然科学基金青年项目1项，浙江省教育厅基金项目1项，温州市科技计划项目2项，温州市科协服务创新项目1项。申报发明专利12项，已授权国内专利4项，美国专利1项。参与编写出版专著1部: 现代仪器分析研究性案例精选(科学出版社)。

主持在研项目

浙江省自然科学基金青年项目(LQ19B020004)，手性含氢键羧酸盐催化剂的设计、合成及应用研究，10万。

浙江省教育厅基金项目(Y201839490)，新型手性羧酸盐催化剂的设计及应用研究，1万。

温州市科技计划项目(G20180015)，新型手性催化剂在药物合成开发中的应用研究，10万。

温州市科协服务创新项目(kjfw35),抗肿瘤活性分子UCS1025A片段合成研究，6万。

温州市科技计划项目(G20220002)，新型 DNA 不对称催化体系的构建及其在手性药物合成中的应用，3万。

研究成果

1. Zhan-Yong Wang, Ting Yang, Kai-Kai Wang, Dongfang Liu, Xueji Ma, Nan Wang, Hong Liu, Aili Sun, Hongxin Liu* Water-promoted catalytic hydrodecarboxylation of conjugated carboxylic acids under open air conditions at room temperature Green Chem., 2023, DOI：10.1039/D3GC00351E.

2. Yimei Song, Chaofei Wu, Jinhai Zhang, Wenhai Zhang, Xin Qin, Yixiao Yang, Guowei Kang*, Jun Jiang*, Hongxin Liu* Switchable multipath cascade cyclization to synthesize bicyclic lactams and succinimides via chemodivergent reaction. Chem. Commun., 2023, 59, 3313-3316.

3. Xin Qin, Jinhai Zhang, Zhan-Yong Wang, Yimei Song, Yixiao Yang, Wenhai Zhang, Hongxin Liu* Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst. RSC Adv., 2023,13, 4782-4786.

4. Yan-Nan Zheng, Xue-Er Cai, Hong-Li Wu, Yu Zhou, Wen-Chan Tian, Yiping Ruan, Hongxin Liu*, Wen-Ting Wei* Metal- and Base-Free Radical Cascade Cyclization/Hydrolysis of CN-Containing 1,6-Enynes with Ethers to Access Polyheterocycles. Chem Asian J. 2023, 18, e202201149 (1-5).

5. Jian Zhang, Jiao-Zhe Li, Ling-Tao Wang, Xuan-Chi Yu, Jun-Hao Zhang, Guo-Ping Ge*, Hongxin Liu* and Wen-Ting Wei*. Photocatalytic Decarboxylative Cyclization of 1,6-Enynes and N-Methacryloyl-2-phenylbenzimidazoles by Potassium Iodide/ Triphenylphosphine Catalysis. Synlett 2023; 34, 143-148.

6. Yu-Tao Guan, Jiao-Zhe Li, Xue-Er Cai, Sen-Jie Hu, Jun-Hao Zhang, Ke-Wei Lei*, Hongxin Liu* and Wen-Ting Wei* Oxone-promoted cyclization/hydrolysis of 1,5-enenitriles initiated via direct C(sp3)-H oxidative functionalization: Access to pyrrolidine-2,4-diones. Synlett, 2022, 33,1917-1924

7. Long Li, Jiao-Zhe Li, Yong-Bin Sun, Chun-Mei Luo, Hui Qiu, Keqi Tang*, Hongxin Liu*, Wen-Ting Wei* Visible-Light-Catalyzed Tandem Radical Addition/1,5-Hydrogen Atom Transfer/Cyclization of 2‑Alkynylarylethers with Sulfonyl Chlorides Org. Lett. 2022, 24, 4704-4709.

8. Boxiao Tang, Yilin Liu*, Yan Liana, Hongxin Liu* Radical annulation using a radical reagent as a two-carbon unit Org. Biomol. Chem., 2022, DOI: 10.1039/D2OB01 833K.

9. Zhan-Yong Wang, Ting Yang, Dongfang Liu, Rongxiang Chen, Nan Wang, Hong Liu, Jia-Rong Li, Kai-Kai, Wang*, Hongxin Liu* Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones Molecules, 2022, 27, 5952.

10. Xin Qin, Chaofei Wu, Fanyun Lu, Zhan-Yong Wang*, Jun Jiang*, Hongxin Liu* The Aldol Reaction of α-Ketoamide with α,β-Unsaturated Ketone in KOH Aqueous Medium ChemistrySelect, 2022, 7, DOI: 10.1002/slct.202104146.

11. Chaofei Wu, Bolun Hu, Hongxin Liu*, Jun Jiang*, Jimin Kim* Arginine-Catalyzed Henry Reaction of α-Keto Amides with Nitromethane on Water ChemistrySelect, 2022, 7, DOI: 10.1002/slct.202104433.

12. Zhan-Yong Wang*, Fumin Shen, Ting Yang, Jun-Kai Zhang, Rongxiang Chen, Kai-Kai Wang*, Hongxin Liu* Carbene-Catalyzed Three-Component Cascade Reaction of Benzofuran-2-ones and Enals: Construction of Spirobenzofuranone-δ-lactones Asian J. Org. Chem., 2021, 10, 3293-3296.

13. Fu-Hua Qin, Qing-Qing Kang, Jun-Yao Zhang, Sen-Jie Hu, Yi Liu, Yiping Ruan∗, Hongxing Zheng, Yi-Lin Fang, Hongxin Liu*, Wen-Ting Wei* Radical Cyclization of Olefinic Amides through α-C(sp³)–H Functionalization of Ketones under Catalyst-, Ligand-, and Base-Free Conditions Synlett , 2021, 32, 905-912.

14. Renyuan Chen, Caidie Xu, Yihao Lei, Hongxin Liu*, Yabin Zhu, Jianfeng Zhang, Long Xu* Facile construction of a family of supramolecular gels with good levofloxacin hydrochloride loading capacity RSC Adv., 2021, 11, 12641-12648.

15. Yi-Lin Liu, Yue-Jun Ouyang*, Hongxing Zheng, Hongxin Liu*, Wen-Ting Wei* Recent advances in acyl radical enabled reactions between aldehydes and alkenes Chem. Commun., 2021, 57, 6111-6120.

16. Caidie Xu, Renlu Han, Hongxin Liu*, Yabin Zhu, Jianfeng Zhang, Long Xu* Construction of Polymeric Micelles for Improving Cancer Chemotherapy by Promoting the Production of Intracellular Reactive Oxygen Species and Self-Accelerating Drug Release ChemistrySelect 2021, 6, 3277-3285.

17. Qing-Qing Kang, Ya-Nan Meng, Jun-Hao Zhang, Long Li, Guo-Ping Ge*, Hongxing Zheng, Hongxin Liu * Wen-Ting Wei * Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp³)-H bonds: facile access to 2,3-dihydrofurans New J. Chem., 2021,45, 13639-13643.

18. Zhan-Yong Wang, Ting Yang, Kai-Kai Wang, Rongxiang Chen, Menghan Liu, Hongxin Liu* Oxidative N-heterocyclic carbene catalyzed formal [3+3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran fused δ-lactones Org. Chem. Front, 2020, 7, 1011-1015.

19. Na Wang, Hongxin Liu*, Hang Gao, Jiafeng Zhou, Longzhangdi Zheng, Juan Li, Hong-Ping Xiao, Xinhua Li, Jun Jiang* Ni(II)-Catalyzed Enantioselective Synthesis of β-Hydroxy Esters with Carboxylate Assistance Org. Lett., 2019, 21, 6684-6689.

20. Chaofei Wu, Juan Li, Hong-Ping Xiao, Xinhua Li, Hongxin Liu*, Jun Jiang* Chiral H-1 NMR of Atropisomeric Quinazolinones with Enantiopure, Frontiers in Chemistry, 2018. 8. 17. 6: 0-300.

21. Zheng Zhu, Quanquan Wu, Chong-Xing Liu, Zhannan Yang*, Hongxin Liu* Catalyst-free benzylic C(sp(3))-H functionalization of methyl quinolines with tryptanthrins, Synthetic. Commun., 2018, 48(9), 1092-1098.

联系方式

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